Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 7/20 | 0.43 |
| ▸ | EDNRB | P24530 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262693 | 0.90 | MAOB (0.54) | MAOBEDNRAEDNRBTP53KMT2A | |
| SCHEMBL89330 | 0.84 | LMNA (0.55) | MAOBKMT2AHPGDMEN1LMNA | |
| SCHEMBL2261371 | 0.82 | MAOB (0.51) | MAOBEDNRAEDNRBTP53KMT2A | |
| SCHEMBL2262151 | 0.80 | MEN1 (0.59) | MAOBEDNRAEDNRBTP53KMT2A | |
| SCHEMBL731053 | 0.76 | CA12 (0.45) | TSHR | |
| SCHEMBL731203 | 0.74 | LMNA (0.62) | MAOBKMT2AMAPTHPGDMEN1 | |
| SCHEMBL12389464 | 0.74 | RAB9A (0.55) | KMT2AALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14002243 | 0.74 | MAOB (0.59) | MAOBKMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL8896523 | 0.74 | MEN1 (0.50) | MAOBKMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL391547 | 0.73 | MEN1 (0.71) | MAOBKMT2AMAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234995-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077385-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |