Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 10/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 10/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 8/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811894 | 1.00 | PTGER3 (0.50) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| Hydrochloric Acid SCHEMBL11788949 | 0.87 | CA1 (0.53) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL30560916 | 0.84 | CA1 (0.53) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL691503 | 0.84 | CA1 (0.53) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL690917 | 0.84 | CA1 (0.53) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL9297750 | 0.84 | NFKB1 (0.67) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL3808382 | 0.81 | CCNC (0.47) | CA1CA2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3808384 | 0.81 | CCNC (0.47) | CA1CA2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2425317 | 0.81 | CA1 (0.62) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL78556 | 0.81 | CA1 (0.62) | PTGER3PTGER2PTGER4PTGER1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881958-B1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1881958-B1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS INC (US) | 2009-09-09 | — | — | EP | disclosed |
| US-7485752-B2 | Diacylglycerol acyltransferase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485752-B2 | Diacylglycerol acyltransferase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485752-B2 | Diacylglycerol acyltransferase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2009-02-03 | — | — | US | disclosed |
| EP-1881958-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006120125-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-16 | — | — | WO | disclosed |
| US-20060258740-A1 | Diacylglycerol acyltransferase inhibitors | VIA PHARMACEUTICALS, INC. | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258740-A1 | Diacylglycerol acyltransferase inhibitors | DGAT2, DGAT1, LCAT | PTGER3 1557/4885PTGER2 1163/4885PTGER4 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.