Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | F2R | P25116 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ESRRG | P62508 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PTPRC | P08575 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814593 | 0.90 | KMT2A (0.63) | MEN1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL6814599 | 0.84 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL3768399 | 0.83 | RAB9A (0.63) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4372468 | 0.83 | P2RX1 (0.71) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4363732 | 0.83 | MEN1 (0.89) | MEN1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL27645970 | 0.83 | SMN1; SMN2 (0.68) | MEN1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL27972423 | 0.83 | MEN1 (0.70) | MEN1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL15778871 | 0.83 | FADS1 (0.70) | MEN1KMT2ASMN1; SMN2TDP1NPC1 | |
| SCHEMBL7821066 | 0.82 | LMNA (0.80) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1810665 | 0.81 | MEN1 (0.81) | MEN1KMT2ASMN1; SMN2TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1386946-B1 | Method for analyzing the sequence of a nucleic acid using 4,7-dichlororhodamine dyes | APPLIED BIOSYSTEMS LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| US-7550570-B2 | Labeling nucleotide sequences with rhodamine dye | APPLIED BIOSYSTEMS, LLC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090093623-A1 | 4,7-DICHLORORHODAMINE DYES | APPLIED BIOSYSTEMS INC. (US) | 2009-04-09 | — | — | US | disclosed |
| CN-1917870-A | Compounds and compositions as lxr modulators | IRM LLC (BM) | 2007-02-21 | — | — | CN | disclosed |
| US-20050112781-A1 | 4,7-dichlororhodamine dyes labeled polynucleotides | APPLIED BIOSYSTEMS, LLC | 2005-05-26 | — | — | US | disclosed |
| EP-1165694-B1 | 4,7-DICHLORORHODAMINE DYES USEFUL AS MOLECULAR PROBES | APPLERA CORP (US) | 2004-09-22 | — | — | EP | disclosed |
| US-6713622-B1 | CONTACTING A 4,7-DICHLORORHODAMINE DYE COMPRISING A LINKING GROUP WITH A POLYNUCLEOTIDE COMPRISING A TERMINAL FUNCTIONALITY COMPLEMENTARY TO THE LINKING GROUP | APPLERA CORPORATION | 2004-03-30 | — | — | US | disclosed |
| EP-1386946-A1 | 4,7-dichlororhodamine dyes useful as molecular probes | Applera Corporation (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6080852-A | FLUORESCENT DYES WITH NARROWER EMISSION SPECTRA AND WHICH ARE SHIFTED TO THE RED; FOR USE IN DIDEOXYNUCLEOTIDE SEQUENCING | THE PERKIN-ELMER CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050112781-A1 | 4,7-dichlororhodamine dyes labeled polynucleotides | POLL, FPR3, DRD4 | MEN1 2667/4885KMT2A 2651/4885SMN1; SMN2 1932/4885 |
| US-20090093623-A1 | 4,7-DICHLORORHODAMINE DYES | POLL, FPR3, DRD4 | MEN1 2574/4885KMT2A 2604/4885SMN1; SMN2 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.