Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815503 | 0.92 | CYP2A6 (0.47) | CYP2A6KCNH2SIGMAR1SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL3817540 | 0.86 | SIGMAR1 (0.52) | CYP2A6SIGMAR1BIRC5KDM4ESMN1; SMN2 | |
| Oxalic Acid SCHEMBL3813389 | 0.83 | THRA (0.43) | CYP2A6SIGMAR1CTNNB1WNT3AOPRM1 | |
| SCHEMBL3816407 | 0.81 | SIGMAR1 (0.53) | CYP2A6SIGMAR1BIRC5 | |
| Hydrochloric Acid SCHEMBL3817320 | 0.80 | SIGMAR1 (0.52) | CYP2A6SIGMAR1BIRC5 | |
| SCHEMBL3816113 | 0.78 | SIGMAR1 (0.55) | CYP2A6SIGMAR1BIRC5KDM4E | |
| Oxalic Acid SCHEMBL3812446 | 0.78 | SIGMAR1 (0.46) | CYP2A6SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8648137 | 0.77 | CYP2A6 (0.54) | CYP2A6SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12269070 | 0.77 | CYP2A6 (0.54) | CYP2A6SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3822570 | 0.76 | SIGMAR1 (0.44) | CYP2A6SIGMAR1SLC6A4SLC6A3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1186594-B1 | N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME | TOYAMA CHEMICAL CO LTD (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-6797726-B1 | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same | TOYAMA CHEMICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1186594-A1 | N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-03-13 | — | — | EP | disclosed |