Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233655 | 0.71 | KEAP1 (0.48) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL10709838 | 0.71 | KEAP1 (0.48) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL6449683 | 0.70 | KIF11 (0.36) | KEAP1NFE2L2CA1CA2CA5A | |
| SCHEMBL29116795 | 0.69 | KEAP1 (0.56) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL11722177 | 0.69 | KEAP1 (0.56) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL28386898 | 0.69 | KEAP1 (0.47) | KEAP1NFE2L2CHRM2CHRM1CYP2D6 | |
| SCHEMBL1403926 | 0.69 | KEAP1 (0.50) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL7748980 | 0.69 | KEAP1 (0.50) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL15412916 | 0.68 | KEAP1 (0.46) | KEAP1NFE2L2KIF11CHRM2CHRM1 | |
| SCHEMBL4475515 | 0.68 | KEAP1 (0.54) | KEAP1NFE2L2KIF11CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263808-B2 | Method for deprotecting aryl or alkyl sulfonamides of primary or secondary amines | SIGNA CHEMISTRY, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| US-20090306391-A1 | METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES | SIGNA CHEMISTRY, LLC (US) | 2009-12-10 | — | — | US | disclosed |
| EP-2035465-A2 | METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES | SIGNA CHEMISTRY LLC (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007095276-A2 | METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES | SIGNA CHEMISTRY, LLC (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306391-A1 | METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES | ARSA, KCNJ1, SIK3 | KEAP1 1327/4885NFE2L2 1251/4885CA1 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.