Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504203 | 0.85 | HPGD (0.54) | ABL1HPGDHTTALDH1A1KMT2A | |
| SCHEMBL3814352 | 0.83 | HPGD (0.51) | ABL1HPGDHTTALDH1A1KMT2A | |
| SCHEMBL3816273 | 0.83 | ABL1 (0.53) | ABL1HPGDALDH1A1KMT2AMAPT | |
| SCHEMBL5618068 | 0.83 | ABL1 (0.61) | ABL1HPGDALDH1A1KMT2AMAPT | |
| SCHEMBL3780795 | 0.82 | HPGD (0.58) | HPGDHTTALDH1A1KMT2AMAPT | |
| SCHEMBL9653150 | 0.81 | ALDH1A1 (0.60) | HPGDHTTALDH1A1KMT2AMAPT | |
| SCHEMBL3816535 | 0.81 | ABL1 (0.54) | ABL1HPGDALDH1A1KMT2AMAPT | |
| SCHEMBL3807311 | 0.80 | ABL1 (0.50) | ABL1HPGDALDH1A1KMT2AMAPT | |
| SCHEMBL1004845 | 0.79 | ALDH1A1 (0.45) | HTTALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL824683 | 0.79 | HPGD (0.51) | HPGDHTTALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180487-B2 | Substituted cyanoindoline derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-23 | — | — | US | disclosed |
| US-20210087182-A1 | NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-03-25 | — | — | US | disclosed |
| WO-2015004481-A1 | IMIDAZO-CONDENSED BICYCLES AS INHIBITORS OF DISCOIDIN DOMAIN RECEPTORS (DDRS) | ASTEX THERAPEUTICS LIMITED (GB) | 2015-01-15 | — | — | WO | disclosed |
| WO-2015004481-A1 | IMIDAZO-CONDENSED BICYCLES AS INHIBITORS OF DISCOIDIN DOMAIN RECEPTORS (DDRS) | ASTEX THERAPEUTICS LIMITED (GB) | 2015-01-15 | — | — | WO | disclosed |
| US-7524855-B2 | Selected benzofuran derivatives | ARPIDA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-20080108610-A1 | Selected Benzofuran Derivatives | ARPIDA AG (CH) | 2008-05-08 | — | — | US | disclosed |
| EP-1838704-A1 | SELECTED BENZOFURAN DERIVATIVES | Arpida AG (CH) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072370-A1 | SELECTED BENZOFURAN DERIVATIVES | ARPIDA AG (CH) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108610-A1 | Selected Benzofuran Derivatives | ABCG2, BPTF, SBDS | ABL1 866/4885HPGD 311/4885HTT 2085/4885 |
| US-20210087182-A1 | NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | NFKBIA, IKBKG, IKBKB | ABL1 877/4885HPGD 1127/4885HTT 4168/4885 |
| US-11180487-B2 | Substituted cyanoindoline derivatives as NIK inhibitors | NFKBIA, MAP3K14, IKBKG | ABL1 691/4885HPGD 881/4885HTT 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.