Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382291 | 0.78 | NPC1 (0.37) | KMT2ACYP19A1PTGER2GRM5SMN1; SMN2 | |
| SCHEMBL1381592 | 0.76 | CYP19A1 (0.41) | CYP3A4CYP3A5CYP19A1 | |
| SCHEMBL3813507 | 0.76 | NAMPT (0.42) | CYP3A4PTGER2GRM5 | |
| SCHEMBL1377766 | 0.76 | CYP19A1 (0.49) | CYP3A4CYP3A5CYP19A1 | |
| SCHEMBL3812181 | 0.75 | LMNA (0.37) | PTGER2 | |
| SCHEMBL3814798 | 0.73 | CYP19A1 (0.43) | CYP3A4CYP3A5CYP19A1PTGER2 | |
| SCHEMBL3811562 | 0.71 | PTGER2 (0.38) | PTGER2 | |
| SCHEMBL1379534 | 0.71 | PTGER2 (0.36) | PTGER2GRM5 | |
| SCHEMBL1379181 | 0.71 | PTGER2 (0.36) | PTGER2GRM5 | |
| SCHEMBL1377228 | 0.71 | CYP1A2 (0.43) | PTGER2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776355-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1776355-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006014877-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |