Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3807722 | 0.93 | BIRC5 (0.42) | KDM4ESIGMAR1CHRM2LMNACHRM1 | |
| Oxalic Acid SCHEMBL3812446 | 0.84 | SIGMAR1 (0.46) | KDM4ESIGMAR1CHRM2LMNACHRM1 | |
| Oxalic Acid SCHEMBL3817540 | 0.84 | SIGMAR1 (0.52) | KDM4ESIGMAR1BIRC5OPRM1OPRK1 | |
| Oxalic Acid SCHEMBL3812890 | 0.83 | SIGMAR1 (0.48) | SIGMAR1 | |
| SCHEMBL3807907 | 0.83 | SIGMAR1 (0.51) | KDM4ESIGMAR1CYP1A2CYP2D6HTT | |
| Oxalic Acid SCHEMBL3808260 | 0.81 | STING1 (0.39) | KDM4ESIGMAR1CHRM2LMNACHRM1 | |
| Oxalic Acid SCHEMBL3808502 | 0.81 | KDM4E (0.38) | KDM4ESIGMAR1CHRM2LMNACHRM1 | |
| Oxalic Acid SCHEMBL3807723 | 0.81 | KDM4E (0.49) | KDM4ESIGMAR1CHRM2LMNACHRM1 | |
| Oxalic Acid SCHEMBL3813198 | 0.81 | SIGMAR1 (0.48) | KDM4ESIGMAR1MRGPRX4OPRM1OPRK1 | |
| SCHEMBL3808077 | 0.79 | ALDH1A1 (0.39) | SIGMAR1ALDH1A1TSHRMRGPRX4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1186594-B1 | N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME | TOYAMA CHEMICAL CO LTD (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-6797726-B1 | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same | TOYAMA CHEMICAL CO., LTD. (JP) | 2004-09-28 | — | — | US | disclosed |
| EP-1186594-A1 | N-ALKOXYALKYL-N,N-DIALKYLAMINE DERIVATIVES OR SALTS THEREOF, AND REMEDIES FOR NERVE DEGENERATION DISEASES CONTAINING THE SAME | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-03-13 | — | — | EP | disclosed |