Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Putrescine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.88 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.78 |
| ▸ | CA12 | O43570 | 3/20 | 0.78 |
| ▸ | CA1 | P00915 | 3/20 | 0.78 |
| ▸ | CA2 | P00918 | 3/20 | 0.78 |
| ▸ | CA3 | P07451 | 3/20 | 0.78 |
| ▸ | CA4 | P22748 | 3/20 | 0.78 |
| ▸ | CA6 | P23280 | 3/20 | 0.78 |
| ▸ | CA5A | P35218 | 3/20 | 0.78 |
| ▸ | CA7 | P43166 | 3/20 | 0.78 |
| ▸ | CA9 | Q16790 | 3/20 | 0.78 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.78 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | BLM | P54132 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ODC1 | P11926 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL648605 | 0.94 | DNM1 (0.89) | NFKB1DNM1CA12CA1CA2 | |
| Ethylenediamine SCHEMBL29052692 | 0.94 | DNM1 (0.89) | NFKB1DNM1CA12CA1CA2 | |
| Putrescine SCHEMBL7599194 | 0.94 | NFKB1 (0.78) | NFKB1DNM1CA12CA1CA2 | |
| Putrescine SCHEMBL21642 | 0.94 | — | — | |
| Putrescine SCHEMBL160836 | 0.94 | NFKB1 (1.00) | NFKB1DNM1CA12CA1CA2 | |
| Ethylenediamine SCHEMBL28326970 | 0.89 | DNM1 (0.80) | NFKB1DNM1CA12CA1CA2 | |
| SCHEMBL25262966 | 0.88 | DNM1 (1.00) | NFKB1DNM1CA12CA1CA2 | |
| Putrescine SCHEMBL22227753 | 0.88 | — | — | |
| SCHEMBL22283336 | 0.88 | DNM1 (1.00) | NFKB1DNM1CA12CA1CA2 | |
| SCHEMBL22684932 | 0.88 | DNM1 (1.00) | NFKB1DNM1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116606525-A | Epoxy resin composite material and preparation method thereof | 江苏澳盛复合材料科技有限公司 | 2023-08-18 | — | — | CN | claimed |
| CN-112742468-A | Titanium-containing molecular sieve, preparation method thereof, catalyst and method for selectively oxidizing hydrocarbons | 中国石油化工股份有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-105026538-B | Aqueous formulations, their preparation and their use in the cleaning of hard surfaces | 巴斯夫欧洲公司 | 2018-03-20 | — | — | CN | disclosed |
| CN-105008465-B | Cation paint additive | 湛新奥地利有限公司 | 2017-08-25 | — | — | CN | disclosed |
| US-20170174797-A1 | LOW VISCOSITY, WATER-BORNE, ACRYLIC MODIFIED ALKYD DISPERSION AND METHOD OF PRODUCTION THEREOF | ARKEMA INC. | 2017-06-22 | — | — | US | disclosed |
| EP-2456798-B1 | PROCESS FOR PREPARING CONDENSATION RESINS AND THE USE THEREOF | BASF SE (DE) | 2017-06-14 | — | — | EP | disclosed |
| EP-2675829-B1 | PROCESS FOR PRODUCING CONDENSATION RESINS | BASF SE (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-20090297779-A1 | POLYURETHANE FOAM ARTICLE | DOW GLOBAL TECHNOLOGIES LLC | 2009-12-03 | — | — | US | disclosed |
| EP-1903072-B1 | Integral skin polyurethane Foam Article | DOW GLOBAL TECHNOLOGIES INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1903072-A1 | Integral skin polyurethane Foam Article | Dow Gloval Technologies Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| EP-0915922-B1 | AN ALKANOLAMINE/CARBON DIOXIDE ADDUCT AND POLYURETHANE FOAM THEREWITH | DOW CHEMICAL CO (US) | 2000-06-07 | — | — | EP | disclosed |
| US-5859285-A | THERMAL DECOMPOSABLE BLOWING AGENT FOR POLYURETHANE FOAMS;WEAR RESISTANCE | THE DOW CHEMICAL COMPANY (US) | 1999-01-12 | — | — | US | disclosed |
| US-5789451-A | THERMAL DECOMPOSABLE BLOWING AGENT | THE DOW CHEMCIAL COMPANY (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0588981-B1 | A PROCESS FOR PREPARING A MICROCELLULAR POLYURETHANE ELASTOMER FROM A SOFT-SEGMENT ISOCYANATE-TERMINATED PREPOLYMER AND MICROCELLULAR POLYURETHANE ELASTOMER OBTAINED THEREBY | DOW CHEMICAL CO (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5510054-A | PREPARED IN THE PRESENCE OF A LIQUID POLYBUTADIENE | DOW ITALIA S.P.A. (IT) | 1996-04-23 | — | — | US | disclosed |
| US-5418259-A | Shoe soles | THE DOW CHEMICAL COMPANY (US) | 1995-05-23 | — | — | US | disclosed |