Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Putrescine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.78 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.70 |
| ▸ | CA12 | O43570 | 3/20 | 0.70 |
| ▸ | CA1 | P00915 | 3/20 | 0.70 |
| ▸ | CA2 | P00918 | 3/20 | 0.70 |
| ▸ | CA3 | P07451 | 3/20 | 0.70 |
| ▸ | CA4 | P22748 | 3/20 | 0.70 |
| ▸ | CA6 | P23280 | 3/20 | 0.70 |
| ▸ | CA5A | P35218 | 3/20 | 0.70 |
| ▸ | CA7 | P43166 | 3/20 | 0.70 |
| ▸ | CA9 | Q16790 | 3/20 | 0.70 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.70 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ODC1 | P11926 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL28326970 | 0.95 | DNM1 (0.80) | NFKB1DNM1CA12CA1CA2 | |
| Ethylenediamine SCHEMBL3440758 | 0.94 | — | — | |
| Putrescine SCHEMBL28230771 | 0.94 | NFKB1 (0.88) | NFKB1DNM1CA12CA1CA2 | |
| Putrescine SCHEMBL5145556 | 0.94 | NFKB1 (0.88) | NFKB1DNM1CA12CA1CA2 | |
| Putrescine SCHEMBL3817271 | 0.94 | NFKB1 (0.88) | NFKB1DNM1CA12CA1CA2 | |
| Ethylenediamine SCHEMBL29052692 | 0.89 | DNM1 (0.89) | NFKB1DNM1CA12CA1CA2 | |
| Ethylenediamine SCHEMBL11147483 | 0.89 | NFKB1 (0.60) | NFKB1DNM1CA12CA1CA2 | |
| SCHEMBL5718543 | 0.89 | DNM1 (0.89) | NFKB1DNM1CA12CA1CA2 | |
| SCHEMBL29160873 | 0.89 | DNM1 (0.89) | NFKB1DNM1CA12CA1CA2 | |
| Ethylenediamine SCHEMBL648605 | 0.89 | DNM1 (0.89) | NFKB1DNM1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261620-A2 | CATIONIC AMPHIPHILES FOR USE IN NUCLEIC ACID TRANSFECTION | Roche Diagnostics Corporation (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001057064-A2 | CATIONIC AMPHIPHILES FOR USE IN NUCLEIC ACID TRANSFECTION | ROCHE DIAGNOSTICS CORPORATION (US) | 2001-08-09 | — | — | WO | disclosed |