Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505822 | 0.83 | C5AR1 (0.33) | KDM4EALDH1A1LMNAGAAMAPT | |
| SCHEMBL72878 | 0.78 | JAK2 (0.33) | KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL3509008 | 0.57 | KDM4E (0.41) | KDM4EALDH1A1LMNAGAAMAPT | |
| SCHEMBL6186637 | 0.53 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15855018 | 0.52 | CHRM3 (0.39) | KDM4EALDH1A1LMNAGAAKMT2A | |
| SCHEMBL17532977 | 0.51 | NOS3 (0.42) | KDM4ELMNAGAAMAPT | |
| SCHEMBL20110472 | 0.51 | L3MBTL1 (0.50) | ALDH1A1 | |
| SCHEMBL7354505 | 0.50 | ADRB2 (0.60) | ALDH1A1 | |
| SCHEMBL7773425 | 0.49 | DRD2 (0.68) | ALDH1A1LMNAGAAMAPT | |
| SCHEMBL18176140 | 0.48 | ACACB (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745033-A4 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORP (US) | 2009-08-26 | — | — | EP | claimed |
| EP-1745033-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2007-01-24 | — | — | EP | claimed |
| WO-2005110416-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |