Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORA | P35398 | 6/20 | 0.68 |
| ▸ | RORC | P51449 | 5/20 | 0.68 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.68 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.68 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.66 |
| ▸ | RORB | Q92753 | 2/20 | 0.56 |
| ▸ | IDH1 | O75874 | 8/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078033 | 0.83 | RORA (0.68) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL12334079 | 0.81 | RORA (1.00) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL6922110 | 0.80 | RORC (0.64) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL2415124 | 0.80 | NR1H3 (1.00) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL6922116 | 0.79 | RORA (0.62) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL6922105 | 0.79 | RORA (0.62) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL7176615 | 0.77 | GAA (0.67) | IDH1ALDH1A1TP53TDP1SMN1; SMN2 | |
| SCHEMBL12334066 | 0.77 | RORA (1.00) | RORARORCNR1H2NR1H4NR1H3 | |
| SCHEMBL1040044 | 0.77 | ALDH1A1 (0.59) | MCL1ALDH1A1TP53TDP1SMN1; SMN2 | |
| SCHEMBL633994 | 0.77 | ALDH1A1 (0.68) | IDH1ALDH1A1TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089009-A2 | USE OF LXR AGONISTS FOR THE TREATMENT OF OSTEOARTHRITIS | Wyeth (US) | 2009-08-19 | — | — | EP | claimed |
| WO-2008036238-A2 | USE OF LXR MODULATORS FOR THE PREVENTION AND TREATMENT OF SKIN AGING | WYETH (US) | 2008-03-27 | — | — | WO | claimed |
| WO-2008036239-A2 | USE OF LXR AGONISTS FOR THE TREATMENT OF OSTEOARTHRITIS | WYETH (US) | 2008-03-27 | — | — | WO | claimed |