N6-Cyclopentyladenosine

N6-Cyclopentyladenosine

SCHEMBL381792

OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)C(O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 6/20 1.00
ADORA2A P29274 4/20 1.00
TSHR P16473 3/20 1.00
ADORA2B P29275 3/20 1.00
ADORA1 P30542 3/20 1.00
PMP22 Q01453 2/20 1.00
SLC29A1 Q99808 2/20 1.00
GAA P10253 1/20 1.00
HTT P42858 1/20 1.00
SIGMAR1 Q99720 1/20 1.00
RXFP1 Q9HBX9 1/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
TP53 P04637 1/20 1.00
NFKB1 P19838 1/20 1.00
HIF1A Q16665 1/20 1.00
SMN1; SMN2 Q16637 1/20 0.98
TDP1 Q9NUW8 1/20 0.98
CYP2C19 P33261 1/20 0.98
THPO P40225 1/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N6-Cyclopentyladenosine SCHEMBL12226873 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL7202975 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL8271466 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL472508 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL472621 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL12200134 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL20226050 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL120481 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
N6-Cyclopentyladenosine SCHEMBL18908968 1.00 ADORA3 (1.00) ADORA3ADORA2ATSHRADORA2BADORA1
SCHEMBL12119008 0.99 TSHR (1.00) ADORA3ADORA2ATSHRADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118845814-A Application of N6-cyclopentyl adenosine, derivatives and salts thereof in treating liver diseases 上海中医药大学 2024-10-29 CN claimed
EP-2704793-B1 REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE UNIV RAMOT (IL) 2019-07-17 EP claimed
US-20180344655-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY 2018-12-06 US claimed
WO-2016183217-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY (US) 2016-11-17 WO claimed
EP-2204154-B1 Association of monosaccharides and adenosine and its cosmetic use ORÉAL L (FR) 2016-10-12 EP claimed
US-9192670-B2 Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2015-11-24 US claimed
US-20110207689-A1 THE TREATMENT OF HEARING LOSS AUCKLAND UNISERVICES LIMITED 2011-08-25 US claimed
EP-2328577-A1 THE TREATMENT OF HEARING LOSS Auckland UniServices Limited (NZ) 2011-06-08 EP claimed
WO-2010019057-A1 THE TREATMENT OF HEARING LOSS AUCKLAND UNISERVICES LIMITED (NZ) 2010-02-18 WO claimed
JP-2004520404-A 2004-07-08 JP claimed
EP-0996453-B1 METHODS FOR THE INHIBITION OF NEURONAL ACTIVITY BY LOCAL DELIVERY OF ADENOSINE MOHLER HANNS (CH) 2004-04-28 EP claimed
EP-1363644-A2 MODULATION OF GSK-3BETA ACTIVITY AND ITS DIFFERENT USES Can-Fite Biopharma Ltd. (IL) 2003-11-26 EP claimed
US-6638914-B1 Use in inducing proliferation of the hematopoietic system, in particular, of bone marrow cells, comprising a pharmaceutically acceptable carrier, excipient or diluent and, as an active ingredient, an effective amount of an CAN-FITE BIOPHARMA LTD. (IL) 2003-10-28 US claimed
WO-2002066020-A2 MODULATION OF GSK-3BETA ACTIVITY AND ITS DIFFERENT USES CAN-FITE BIOPHARMA LTD. (IL) 2002-08-29 WO claimed
US-20260008805-A1 ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE BIOINTERVENE INC (US) 2026-01-08 US disclosed
US-20250295604-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY 2025-09-25 US disclosed
EP-4590677-A2 ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE Biointervene, Inc. (US) 2025-07-30 EP disclosed
WO-1993008206-A1 NOVEL 2,6-DISUBSTITUTED PURINE DERIVATIVES NOVO NORDISK A/S (DK) 1993-04-29 WO disclosed
WO-1988000192-A1 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES WARNER-LAMBERT COMPANY (US) 1988-01-14 WO disclosed
EP-0232813-A2 N6-substituted Adenosines WARNER-LAMBERT COMPANY (US) 1987-08-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110207689-A1 THE TREATMENT OF HEARING LOSS ADORA1, ADORA2A, ADORA3 ADORA3 3/4885ADORA2A 2/4885TSHR 561/4885
US-20260008805-A1 ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE ADORA2B, ADORA2A, ADORA1 ADORA3 4/4885ADORA2A 2/4885TSHR 561/4885
US-20250295604-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS PHLPP1, PHLPP2, PLAA ADORA3 32/4885ADORA2A 10/4885TSHR 3522/4885
US-20180344655-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS PHLPP1, PHLPP2, PLAA ADORA3 32/4885ADORA2A 10/4885TSHR 3522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.