Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.60 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38035 | 0.89 | PDE5A (0.55) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL37626 | 0.86 | PDE5A (0.80) | PDE5AHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL46456 | 0.84 | PDE5A (0.57) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL38484 | 0.84 | PDE5A (0.57) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL46310 | 0.80 | PDE5A (0.74) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL37644 | 0.79 | PDE5A (0.53) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL37942 | 0.77 | PDE5A (0.78) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL38179 | 0.77 | PDE5A (0.46) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL38381 | 0.77 | PDE5A (0.47) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL38005 | 0.76 | PDE5A (0.69) | PDE5ARNASEH1KDM4ECDC7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |