Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.55 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38180 | 0.89 | PDE5A (0.60) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL38530 | 0.87 | PDE5A (0.73) | PDE5ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL46456 | 0.80 | PDE5A (0.57) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL38484 | 0.80 | PDE5A (0.57) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL37691 | 0.78 | MAPT (0.50) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL46310 | 0.76 | PDE5A (0.74) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL37626 | 0.76 | PDE5A (0.80) | PDE5ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL37644 | 0.75 | PDE5A (0.53) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL37942 | 0.73 | PDE5A (0.78) | PDE5ARNASEH1RAB9AKDM4ELMNA | |
| SCHEMBL38179 | 0.73 | PDE5A (0.46) | PDE5ARNASEH1CDC7CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |