Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44200 | 0.87 | PDE5A (0.63) | PDE5ARAB9AMEN1NPC1PKM | |
| SCHEMBL37495 | 0.78 | RNASEH1 (0.46) | PDE5ARNASEH1RAB9AMEN1KMT2A | |
| SCHEMBL38180 | 0.77 | PDE5A (0.60) | PDE5ARNASEH1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL38484 | 0.77 | PDE5A (0.57) | PDE5ARNASEH1RAB9AMEN1NPC1 | |
| SCHEMBL37644 | 0.76 | PDE5A (0.53) | PDE5ARNASEH1RAB9AMEN1NPC1 | |
| SCHEMBL38275 | 0.75 | PDE5A (0.69) | PDE5ARAB9AMEN1NPC1PKM | |
| SCHEMBL46456 | 0.75 | PDE5A (0.57) | PDE5ARNASEH1RAB9AMEN1NPC1 | |
| SCHEMBL38381 | 0.74 | PDE5A (0.47) | PDE5ARNASEH1RAB9AMEN1NPC1 | |
| SCHEMBL38035 | 0.73 | PDE5A (0.55) | PDE5ARNASEH1RAB9AMEN1KMT2A | |
| SCHEMBL38977 | 0.73 | RNASEH1 (0.49) | PDE5ARNASEH1RAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |