Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.57 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46296 | 0.91 | PDE5A (0.56) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL10084040 | 0.90 | PDE5A (0.59) | PDE5AALOX5CDC7CCNE1CDK2 | |
| SCHEMBL46289 | 0.87 | PDE5A (0.76) | PDE5APTGESALOX5CDC7CCNE1 | |
| SCHEMBL46456 | 0.86 | PDE5A (0.57) | PDE5ARNASEH1PTGESALOX5CDC7 | |
| SCHEMBL38373 | 0.85 | PDE5A (0.61) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL38180 | 0.84 | PDE5A (0.60) | PDE5ARNASEH1CDC7CCNE1CDK2 | |
| SCHEMBL4522382 | 0.84 | PDE5A (0.57) | PDE5ARNASEH1PTGESALOX5KMT2A | |
| SCHEMBL10083509 | 0.83 | PDE5A (0.58) | PDE5APTGESALOX5CDC7CCNE1 | |
| SCHEMBL46291 | 0.82 | PDE5A (0.50) | PDE5ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL38035 | 0.80 | PDE5A (0.55) | PDE5ARNASEH1CDC7CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |