Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380987 | 0.90 | ALDH1A1 (0.40) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL381695 | 0.83 | OPRM1 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL19244872 | 0.83 | OPRM1 (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL381593 | 0.82 | BCHE (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL19244815 | 0.82 | ACP3 (0.40) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL15170368 | 0.81 | ACP3 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL381185 | 0.81 | ACP3 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL414657 | 0.80 | ACP3 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL16674214 | 0.80 | PNMT (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL19244821 | 0.80 | ACP3 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408751-B1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | BAYER IP GMBH (DE) | 2017-08-23 | — | — | EP | disclosed |
| EP-2408751-A1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | Bayer Pharma Aktiengesellschaft (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010105770-A1 | SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-23 | — | — | WO | disclosed |