SCHEMBL381889

SCHEMBL381889

C1=CC2(C=Cc3ccccc3O2)Oc2ccccc21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 2/20 0.52
HTR2B P41595 1/20 0.52
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
ADRA1D P25100 1/20 0.35
ADRA1A P35348 1/20 0.35
ADRA1B P35368 1/20 0.35
MAPT P10636 3/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
UBE2N P61088 1/20 0.35
GAA P10253 1/20 0.32
ALOX5 P09917 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14077641 0.81 HTR2C (0.41) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL8680618 0.80 ADRA1D (0.40) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL11586220 0.80 HTR2C (0.38) HTR2CHTR2BHTTNPSR1MAPT
SCHEMBL6139999 0.80 ALDH1A1 (0.51) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL30612751 0.80 ALDH1A1 (0.51) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL10933341 0.78 HTR2C (0.36) HTR2CHTR2BHTTNPSR1MAPT
SCHEMBL6433379 0.77 HTR2C (0.49) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL5866015 0.77 HTR2C (0.49) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL1536905 0.77 HTR2C (0.49) HTR2CHTR2BHTTNPSR1ADRA1D
SCHEMBL1748567 0.77 HTR2C (0.49) HTR2CHTR2BHTTNPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6551710-B1 Primer composition comprises dithiol or polythiol compound and allyl or vinyl monomer; coating composition can further comprise photochromic dyes and additional polymerizable monomers; coatings for lenses SOLA INTERNATIONAL HOLDINGS, LTD. (AU) 2003-04-22 US claimed
US-5759729-A A DRY TONER COMPRISING A RESIN, PHOTOCHROMATIC SPIROPYRAN, -OXAZINE OR -THIOPYRAN DYE AND A CHARGE CONTROL AGENT;ELECTROGRAPHY; XEROGRAPHY XEROX CORPORATION (US) 1998-06-02 US claimed
WO-1997027223-A1 PROCESS FOR PREPARING OPTICAL ARTICLES SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1997-07-31 WO claimed
US-20230323051-A1 WATER-SOLUBLE FILM BASED DELIVERY SYSTEMS FOR COLORANTS, GLITTER, AND OTHER ARTISTIC EFFECTS CRAYOLA LLC (US) 2023-10-12 US disclosed
US-20230323595-A1 WATER-SOLUBLE FILM BASED DELIVERY SYSTEMS FOR COLORANTS, GLITTER, AND OTHER CHEMISTRIES CRAYOLA LLC (US) 2023-10-12 US disclosed
WO-2023175193-A2 COATED LENS AND METHOD FOR MANUFACTURING THE SAME CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2023-09-21 WO disclosed
US-11754860-B2 Photochromic lens with laminated film, method for producing a photochromic lens, and a spectacle frame CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2023-09-12 US disclosed
US-11746235-B2 Two part silicone moldable eraser CRAYOLA LLC (US) 2023-09-05 US disclosed
US-11007813-B2 Integrated highlighting and shading marker system CRAYOLA LLC (US) 2021-05-18 US disclosed
US-20200399472-A1 TWO PART SILICONE MOLDABLE ERASER CRAYOLA LLC (US) 2020-12-24 US disclosed
US-20200201079-A1 PHOTOCHROMIC LENS WITH LAMINATED FILM, METHOD FOR PRODUCING A PHOTOCHROMIC LENS, AND A SPECTACLE FRAME CARL ZEISS VISION INTERNATIONAL GMBH (DE) 2020-06-25 US disclosed
US-5633109-A Ink compositions with liposomes containing photochromic compounds XEROX CORPORATION (US) 1997-05-27 US disclosed
US-5593486-A Photochromic hot melt ink compositions XEROX CORPORATION (US) 1997-01-14 US disclosed
US-5551973-A LIQUID CRYSTAL GEL PHASE, MICROEMULSION PHASE XEROX CORPORATION (US) 1996-09-03 US disclosed
WO-1996018928-A1 INCORPORATING PHOTOCHROMIC MOLECULES IN LIGHT TRANSMISSIBLE ARTICLES SOLA INTERNATIONAL HOLDINGS LTD. (AU) 1996-06-20 WO disclosed
US-4348508-A 3-Substituted-7-alkoxy-2,2'-Spirobi[2H-1-benzopyrans] ARMSTRONG WORLD INDUSTRIES, INC. (US) 1982-09-07 US disclosed
US-4346186-A ULTRAVIOLET IRRADIATION ARMSTRONG WORLD INDUSTRIES, INC. (US) 1982-08-24 US disclosed
US-4345073-A 7,7'-Diamino derivatives of 2,2'-spirodibenzopyranes BASF AKTIENGESELLSCHAFT (DE) 1982-08-17 US disclosed
US-4316027-A DYE INTERMEDIATES USED IN THE MANUFACTURE OF PRESSURE SENSITIVE RECORDING MATERIAL BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US disclosed
US-4110348-A PRESSURE SENSITIVE RECORDING BASF AKTIENGESELLSCHAFT (DE) 1978-08-29 US disclosed