Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068928 | 0.85 | AAK1 (0.43) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL1068927 | 0.85 | AAK1 (0.43) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL12087979 | 0.83 | AAK1 (0.50) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL5928301 | 0.83 | MEN1 (0.51) | AAK1ALDH1A1TSHRRAB9APOLB | |
| SCHEMBL7711956 | 0.83 | AAK1 (0.47) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL1741951 | 0.82 | AAK1 (0.46) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL2560172 | 0.81 | AAK1 (0.44) | AAK1CES2CES1ALDH1A1TSHR | |
| SCHEMBL27842018 | 0.81 | AAK1 (0.43) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL28884384 | 0.81 | AAK1 (0.45) | AAK1PGRADRA2AADRA2BHTR2A | |
| SCHEMBL28367766 | 0.81 | AAK1 (0.45) | AAK1PGRADRA2AADRA2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342558-B1 | 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders | SEARLE & CO (US) | 1994-02-02 | — | — | EP | claimed |
| JP-1128964-A | — | — | None | — | — | JP | disclosed |
| CN-120025302-A | Synthesis method of Fmoc-L-4' -tetrahydropyranyl glycine | 康化（上海）新药研发有限公司 | 2025-05-23 | — | — | CN | disclosed |
| US-12281101-B2 | Bicyclic lactams and methods of use thereof | GENENTECH, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| CN-117417292-B | Heteroaryl-containing unnatural amino acid and application thereof | 浙江新码生物医药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-117417292-A | Heteroaryl-containing unnatural amino acid and application thereof | 浙江新码生物医药有限公司 | 2024-01-19 | — | — | CN | disclosed |
| US-20220348559-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2022-11-03 | — | — | US | disclosed |
| CN-115197139-A | Preparation method of roxasistat and intermediate thereof | 南京方生和医药科技有限公司 | 2022-10-18 | — | — | CN | disclosed |
| US-10988459-B2 | Bicyclic lactams and methods of use thereof | GENENTECH, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-10835520-B2 | Phenyl derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-11-17 | — | — | US | disclosed |
| US-7700589-B2 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-04-20 | — | — | US | disclosed |
| EP-2157856-A1 | HERBICIDALLY EFFECTIVE COMPOSITION | Basf Se (DE) | 2010-03-03 | — | — | EP | disclosed |
| US-7538115-B2 | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-05-26 | — | — | US | disclosed |
| WO-2008152074-A1 | HERBICIDALLY EFFECTIVE COMPOSITION | BASF SE (DE) | 2008-12-18 | — | — | WO | disclosed |
| US-20070244099-A1 | CGRP Antagonists | RUDOLF KLAUS | 2007-10-18 | — | — | US | disclosed |
| US-7026312-B2 | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-04-11 | — | — | US | disclosed |
| US-20050215546-A1 | Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-09-29 | — | — | US | disclosed |
| US-20030236282-A1 | Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. (DE) | 2003-12-25 | — | — | US | disclosed |
| US-5691356-A | ANTICOAGULANTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| JP-H01128964-A | NEW FLUORINATED DERIVATIVE OF AMINO ACID USEFUL PARTICULARLY AS SURFACTANT OR COSURFACTANT AND PREPARATION FOR BIOMEDICAL USE INCORPORATING THE DERIVATIVE | APPL & TRANSFERTS DE TECHNOL AVANCEES ATTA | 1989-05-22 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220348559-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | LSS, LPXN, CYP1B1 | AAK1 4329/4885PGR 3418/4885ADRA2A 2316/4885 |
| US-10988459-B2 | Bicyclic lactams and methods of use thereof | LSS, LPXN, CYP1B1 | AAK1 4329/4885PGR 3418/4885ADRA2A 2316/4885 |
| US-20070244099-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | AAK1 1536/4885PGR 864/4885ADRA2A 80/4885 |
| US-12281101-B2 | Bicyclic lactams and methods of use thereof | LSS, LPXN, CYP1B1 | AAK1 4329/4885PGR 3418/4885ADRA2A 2316/4885 |
| US-20030236282-A1 | Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | P2RX5, CALCRL, ADRA1D | AAK1 2595/4885PGR 1517/4885ADRA2A 33/4885 |
| US-10835520-B2 | Phenyl derivative | S1PR2, S1PR1, S1PR3 | AAK1 2761/4885PGR 1179/4885ADRA2A 62/4885 |
| US-20050215546-A1 | Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof | P2RX3, P2RX5, P2RX2 | AAK1 2942/4885PGR 958/4885ADRA2A 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.