Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817654 | 0.82 | CYP3A4 (0.37) | DPP4DPP9DPP7UBE2MDCUN1D1 | |
| SCHEMBL3819363 | 0.82 | ATM (0.39) | S1PR1SLC6A2SLC6A3OPRM1DPP4 | |
| SCHEMBL3821795 | 0.81 | GRIN2A (0.41) | S1PR1SLC6A2SLC6A3SLC6A4OPRM1 | |
| SCHEMBL3821794 | 0.80 | OPRM1 (0.39) | S1PR1OPRM1MAOA | |
| SCHEMBL3059109 | 0.79 | ACHE (0.39) | S1PR1SLC6A2SLC6A3SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL3064216 | 0.78 | ACHE (0.39) | S1PR1SLC6A2SLC6A3SLC6A4OPRM1 | |
| SCHEMBL3819801 | 0.77 | ATM (0.40) | OPRM1DPP4DPP9DPP7OPRD1 | |
| SCHEMBL3819226 | 0.76 | CNR1 (0.40) | OPRM1UBE2MDCUN1D1 | |
| SCHEMBL3064159 | 0.76 | CHRM1 (0.42) | — | |
| SCHEMBL13090640 | 0.75 | S1PR1 (0.38) | S1PR1SLC6A2SLC6A3SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |