Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A | Q12879 | 6/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821794 | 0.82 | OPRM1 (0.39) | S1PR1OPRM1 | |
| SCHEMBL3819367 | 0.81 | S1PR1 (0.36) | GRIN2AGRIA2S1PR1SLC6A2SLC6A4 | |
| SCHEMBL3819363 | 0.79 | ATM (0.39) | S1PR1SLC6A2SLC6A3OPRM1 | |
| SCHEMBL3059109 | 0.79 | ACHE (0.39) | S1PR1SLC6A2SLC6A4SLC6A3OPRM1 | |
| Hydrochloric Acid SCHEMBL3064216 | 0.78 | ACHE (0.39) | S1PR1SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL3064159 | 0.77 | CHRM1 (0.42) | KDM1A | |
| SCHEMBL13090640 | 0.77 | S1PR1 (0.38) | GRIN2AGRIA2S1PR1SLC6A2SLC6A4 | |
| SCHEMBL4734946 | 0.76 | LMNA (0.58) | OPRM1 | |
| SCHEMBL3819801 | 0.76 | ATM (0.40) | OPRM1OPRD1OPRK1 | |
| SCHEMBL3819014 | 0.75 | CNR2 (0.46) | CNR1CNR2OPRM1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |