Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176408 | 1.00 | ATM (0.42) | ATMCHRM2CHRM1CHRM3TDP1 | |
| SCHEMBL3819194 | 0.91 | ATM (0.40) | ATMCHRM2CHRM1CHRM3OPRM1 | |
| SCHEMBL3818460 | 0.88 | ALDH1A1 (0.37) | ATMCHRM2CHRM1CHRM3TDP1 | |
| SCHEMBL8189715 | 0.86 | CNR2 (0.51) | TDP1LTB4R2CNR2CNR1 | |
| SCHEMBL3822100 | 0.86 | CNR2 (0.51) | TDP1LTB4R2CNR2CNR1 | |
| SCHEMBL3819264 | 0.84 | FFAR2 (0.35) | ATMCHRM2CHRM1CHRM3OPRM1 | |
| SCHEMBL3822517 | 0.83 | LTB4R2 (0.46) | CHRM2CHRM1CHRM3OPRM1TMEM97 | |
| SCHEMBL3823354 | 0.78 | CACNA1H (0.40) | TDP1KDM4EALDH1A1TSHRLTB4R2 | |
| SCHEMBL3820052 | 0.78 | CACNA1H (0.40) | TDP1KDM4EALDH1A1TSHRLTB4R2 | |
| SCHEMBL3819420 | 0.77 | KDM4E (0.39) | ATMCHRM2CHRM1CHRM3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |