Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823354 | 1.00 | CACNA1H (0.40) | CACNA1HCNR2CNR1ALDH1A1KDM4E | |
| SCHEMBL3818460 | 0.88 | ALDH1A1 (0.37) | ALDH1A1KDM4ELTB4R2TSHRTDP1 | |
| SCHEMBL3822100 | 0.87 | CNR2 (0.51) | CNR2CNR1LTB4R2TDP1MEN1 | |
| SCHEMBL8189715 | 0.87 | CNR2 (0.51) | CNR2CNR1LTB4R2TDP1MEN1 | |
| SCHEMBL8187625 | 0.83 | TDP1 (0.40) | ALDH1A1KDM4ELTB4R2TSHRTDP1 | |
| SCHEMBL3824486 | 0.82 | CACNA1H (0.41) | CACNA1HCNR2CNR1ALDH1A1KDM4E | |
| SCHEMBL4736030 | 0.81 | CACNA1H (0.47) | CACNA1HCNR2CNR1ALDH1A1KDM4E | |
| SCHEMBL3825186 | 0.81 | CACNA1H (0.44) | CACNA1HCNR2CNR1LTB4R2AOC3 | |
| SCHEMBL3071006 | 0.79 | CACNA1H (0.47) | CACNA1HCNR2ALDH1A1KDM4ELTB4R2 | |
| SCHEMBL3819794 | 0.78 | ATM (0.42) | CNR2CNR1ALDH1A1KDM4ELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |