Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12677225 | 0.75 | ATAD2 (0.53) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL19557306 | 0.73 | ALDH1A1 (0.47) | DAOHRH4MAPTALDH1A1KDM4E | |
| SCHEMBL29997480 | 0.72 | ATAD2 (0.62) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL4641753 | 0.72 | ATAD2 (0.62) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL24390514 | 0.71 | ATAD2 (0.66) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL23453014 | 0.70 | ATAD2 (0.47) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL5790265 | 0.68 | DAO (0.53) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL12615150 | 0.68 | DAO (0.53) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL25248466 | 0.68 | DAO (0.53) | ATAD2DAOHRH4MAPTSNCA | |
| SCHEMBL4420086 | 0.68 | DAO (0.53) | ATAD2DAOHRH4MAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242983-B2 | Viral inhibitors | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2016-01-26 | — | — | US | disclosed |
| EP-2094702-B1 | VIRAL INHIBITORS | GILEAD SCIENCES INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-20140221382-A1 | VIRAL INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8722677-B2 | Viral inhibitors | GILEAD SCIENCES, INC. (US) | 2014-05-13 | — | — | US | disclosed |
| US-20120258969-A1 | VIRAL INHIBITORS | GILEAD SCIENCES, INC. | 2012-10-11 | — | — | US | disclosed |
| US-8263612-B2 | Viral inhibitors | GILEAD SCIENCES, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| EP-2094702-A2 | VIRAL INHIBITORS | Gilead Sciences, Inc. (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008133669-A2 | VIRAL INHIBITORS | GILEAD SCIENCES, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20080207678-A1 | Propylaxic or therapy of viral infections; using pyrrolo( 2,3-c)pyridine | GILEAD SCIENCES, INC. | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207678-A1 | Propylaxic or therapy of viral infections; using pyrrolo( 2,3-c)pyridine | PNPO, PRDX6, PRDX4 | ATAD2 3689/4885DAO 1135/4885HRH4 706/4885 |
| US-20140221382-A1 | VIRAL INHIBITORS | ZC3HAV1, DDX5, ZC3HAV1L | ATAD2 2374/4885DAO 1353/4885HRH4 1932/4885 |
| US-20120258969-A1 | VIRAL INHIBITORS | ZC3HAV1, DDX5, ZC3HAV1L | ATAD2 2374/4885DAO 1353/4885HRH4 1932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.