Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.62 |
| ▸ | FEN1 | P39748 | 1/20 | 0.62 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275775 | 0.88 | KMT2A (0.67) | ERCC5FEN1MAPTSMN1; SMN2HPGD | |
| SCHEMBL29035576 | 0.86 | KMT2A (0.64) | ERCC5FEN1MAPTSMN1; SMN2HPGD | |
| SCHEMBL10001233 | 0.86 | SMN1; SMN2 (0.66) | ERCC5FEN1HAO1MAPTSMN1; SMN2 | |
| SCHEMBL4270804 | 0.84 | MAPT (0.61) | ERCC5FEN1HAO1MAPTSMN1; SMN2 | |
| SCHEMBL27182280 | 0.84 | ERCC5 (0.77) | ERCC5FEN1HAO1MAPTSMN1; SMN2 | |
| SCHEMBL13871104 | 0.83 | ERCC5 (0.56) | ERCC5FEN1HAO1MAPTSMN1; SMN2 | |
| SCHEMBL10986985 | 0.83 | HDAC1 (0.63) | ERCC5FEN1HAO1MAPTSMN1; SMN2 | |
| SCHEMBL1221520 | 0.83 | MAPT (0.54) | ERCC5FEN1HAO1MAPTSMN1; SMN2 | |
| SCHEMBL14918369 | 0.82 | CA1 (0.52) | MAPTSMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL1728532 | 0.82 | ERCC5 (0.68) | ERCC5FEN1MAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096111-A1 | PYRAZOLES AND USE THEREOF AS DRUGS | Japan Tobacco Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO, INC. (JP) | 2009-02-05 | — | — | US | disclosed |
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO, INC. (JP) | 2009-02-05 | — | — | US | disclosed |
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO, INC. (JP) | 2009-02-05 | — | — | US | disclosed |
| US-3993670-A | OPTICAL BRIGHTENERS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-23 | — | — | US | disclosed |
| US-3971731-A | OPTICAL BRIGHTENER, UV ABSORBER | BAYER AKTIENGESELLSCHAFT (DT) | 1976-07-27 | — | — | US | disclosed |
| US-3950381-A | Preparation of aroyl acidic esters | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | PYGL, GYS2, G6PC1 | ERCC5 4741/4885FEN1 1839/4885HAO1 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.