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SCHEMBL382322

SCHEMBL382322

COc1ccc(C(OC(C)([C@H]2O[C@@H](n3ccc(N)nc3=O)C(F)(F)[C@@H]2O)C(c2ccccc2)(c2ccccc2)c2ccc(OC)cc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PDE4D Q08499 1/20 0.46
▸ PDE3A Q14432 1/20 0.46
▸ SLC29A1 Q99808 1/20 0.46
▸ POLA1 P09884 2/20 0.41
▸ TYMP P19971 1/20 0.34
▸ LMNA P02545 1/20 0.32
▸ THRB P10828 1/20 0.32
▸ MTOR P42345 1/20 0.32
▸ MDM2 Q00987 1/20 0.32
▸ NCOA1 Q15788 1/20 0.32
▸ NCOA3 Q9Y6Q9 1/20 0.32
▸ ST6GAL1 P15907 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL383202 0.87 PDE4D (0.45) PDE4DPDE3ASLC29A1POLA1TYMP
SCHEMBL383275 0.84 LMNA (0.43) TYMPLMNATHRBMTORMDM2
SCHEMBL383885 0.80 PDE4D (0.44) PDE4DPDE3ASLC29A1POLA1TYMP
SCHEMBL383446 0.80 PDE4D (0.46) PDE4DPDE3ASLC29A1POLA1TYMP
SCHEMBL3793139 0.74 PDE4D (0.40) PDE4DPDE3ASLC29A1POLA1TYMP
SCHEMBL3789728 0.74 LMNA (0.43) TYMPLMNATHRBMTORMDM2
SCHEMBL383426 0.73 LMNA (0.42) TYMPLMNATHRBMTORMDM2
SCHEMBL26123700 0.71 PDE4D (0.37) PDE4DPDE3ASLC29A1POLA1TYMP
SCHEMBL20610798 0.70 PDE4D (0.61) PDE4DPDE3ASLC29A1POLA1LMNA
SCHEMBL4569700 0.70 PDE4D (0.61) PDE4DPDE3ASLC29A1POLA1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408306-A1 SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGS Alios Biopharma, Inc. (US) 2012-01-25 — — EP disclosed