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Sugi Predict / Compounds / SCHEMBL383426

SCHEMBL383426

SCHEMBL383426

CCCC(OC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1)([C@H]1O[C@@H](n2ccc(N)nc2=O)[C@H](O)[C@@H]1O)C(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.42
▸ THRB P10828 1/20 0.42
▸ MTOR P42345 1/20 0.42
▸ MDM2 Q00987 1/20 0.42
▸ NCOA1 Q15788 1/20 0.42
▸ NCOA3 Q9Y6Q9 1/20 0.42
▸ TYMP P19971 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ ST6GAL1 P15907 6/20 0.39
▸ NT5E P21589 1/20 0.37
▸ TSHR P16473 1/20 0.36
▸ GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3789728 0.94 LMNA (0.43) LMNATHRBMTORMDM2NCOA1
SCHEMBL383275 0.86 LMNA (0.43) LMNATHRBMTORMDM2NCOA1
SCHEMBL383202 0.85 PDE4D (0.45) LMNATHRBMTORMDM2NCOA1
SCHEMBL9752464 0.79 LMNA (0.49) LMNATHRBMTORMDM2NCOA1
SCHEMBL5710025 0.79 TYMP (0.62) LMNATHRBMTORMDM2NCOA1
SCHEMBL1317526 0.75 NT5E (0.45) LMNATHRBMTORMDM2NCOA1
SCHEMBL1318619 0.75 NT5E (0.45) LMNATHRBMTORMDM2NCOA1
SCHEMBL5150771 0.75 NT5E (0.51) LMNATHRBMTORMDM2NCOA1
SCHEMBL30274680 0.75 LMNA (0.40) LMNATHRBMTORMDM2NCOA1
SCHEMBL383849 0.74 L3MBTL1 (0.40) LMNATHRBMTORMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408306-A1 SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGS Alios Biopharma, Inc. (US) 2012-01-25 — — EP disclosed