Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.42 |
| ▸ | RARG | P13631 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 4/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382090 | 0.87 | RARA (0.48) | RARBRARGNPC1LMNARAB9A | |
| SCHEMBL382839 | 0.86 | RARG (0.44) | RARBRARGMAOBMAPTTP53 | |
| SCHEMBL382244 | 0.85 | RARB (0.56) | RARBRARGNPC1LMNARAB9A | |
| SCHEMBL381770 | 0.84 | RARG (0.58) | RARBRARGDHFRMAPTRARA | |
| SCHEMBL382163 | 0.83 | HRH3 (0.43) | NPC1LMNARAB9AHSD17B10MAPT | |
| SCHEMBL382994 | 0.80 | RARA (0.51) | RARBRARGNPC1LMNARAB9A | |
| SCHEMBL4577375 | 0.79 | RARB (0.51) | RARBRARGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL383525 | 0.74 | RARG (0.62) | RARBRARGNPC1LMNARAB9A | |
| SCHEMBL382740 | 0.73 | RARG (0.61) | RARBRARGDHFRMAPTRARA | |
| SCHEMBL380874 | 0.72 | RARA (0.51) | RARBRARGNPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831149-B1 | NOVEL LIGANDS THAT MODULATE RAR RECEPTORS AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RES & DEV (FR) | 2012-01-25 | — | — | EP | disclosed |