Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | RNF4 | P78317 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819221 | 0.87 | CHRM2 (0.44) | CHRM1CHRM3CHRM2RNF4MEN1 | |
| SCHEMBL3819010 | 0.81 | RNF4 (0.47) | CHRM1CHRM3CHRM2RNF4MEN1 | |
| SCHEMBL3819801 | 0.79 | ATM (0.40) | CHRM1CHRM3CHRM2TDP1MEN1 | |
| SCHEMBL3819226 | 0.74 | CNR1 (0.40) | CHRM1CHRM3CHRM2MEN1KMT2A | |
| SCHEMBL3819014 | 0.74 | CNR2 (0.46) | DRD2DRD3ALDH1A1LMNAOPRM1 | |
| SCHEMBL4734150 | 0.74 | KMT2A (0.48) | CHRM1CHRM3CHRM2MEN1KMT2A | |
| SCHEMBL4737523 | 0.73 | ALDH1A1 (0.45) | CHRM1CHRM3CHRM2RNF4MEN1 | |
| SCHEMBL3053871 | 0.73 | CNR2 (0.41) | CHRM1CHRM3CHRM2RNF4DRD2 | |
| SCHEMBL27594337 | 0.73 | CNR1 (0.41) | TDP1TRPM8DRD2DRD3ALDH1A1 | |
| SCHEMBL4737670 | 0.72 | SMN1; SMN2 (0.46) | CHRM1CHRM3CHRM2RNF4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |