Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RNF4 | P78317 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737523 | 0.83 | ALDH1A1 (0.45) | SMN1; SMN2TP53MAPTGAACHRM2 | |
| SCHEMBL4739034 | 0.83 | ACHE (0.40) | CHRM2CHRM3CHRM1MEN1KMT2A | |
| SCHEMBL3819010 | 0.73 | RNF4 (0.47) | CHRM2CHRM3CHRM1RNF4MEN1 | |
| SCHEMBL4736992 | 0.73 | MEN1 (0.43) | SMN1; SMN2TP53MAPTGAACHRM2 | |
| SCHEMBL3824522 | 0.72 | CHRM1 (0.47) | CHRM2CHRM3CHRM1ALDH1A1LMNA | |
| SCHEMBL4734150 | 0.71 | KMT2A (0.48) | CHRM2CHRM3CHRM1ALDH1A1LMNA | |
| SCHEMBL4738910 | 0.71 | CACNA1H (0.42) | SMN1; SMN2TP53MAPTALDH1A1HTT | |
| SCHEMBL17351879 | 0.71 | ALOX15 (0.56) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4735333 | 0.71 | ALDH1A1 (0.48) | TP53CHRM2CHRM3CHRM1ALDH1A1 | |
| SCHEMBL3819221 | 0.70 | CHRM2 (0.44) | CHRM2CHRM3CHRM1RNF4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |