SCHEMBL3824666

SCHEMBL3824666

O=C(C(=O)c1ccc(N2CCOCC2)cc1)c1ccc(N2CCOCC2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.66
ALDH1A1 P00352 5/20 0.61
HPGD P15428 2/20 0.61
KDM4E B2RXH2 2/20 0.61
ALOX15 P16050 1/20 0.61
HSD17B10 Q99714 1/20 0.61
MAPT P10636 9/20 0.57
NPC1 O15118 4/20 0.57
RAB9A P51151 4/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
TP53 P04637 2/20 0.57
HDAC8 Q9BY41 2/20 0.57
HDAC6 Q9UBN7 2/20 0.57
ATM Q13315 1/20 0.55
MAOB P27338 1/20 0.55
PKM P14618 1/20 0.55
MAPK1 P28482 1/20 0.55
KMO O15229 1/20 0.54
PRKDC P78527 2/20 0.54
LMNA P02545 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14982133 0.93 GSK3B (0.58) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL14982132 0.93 ALDH1A1 (0.61) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL16595516 0.90 GSK3B (0.60) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL2742813 0.88 NPC1 (0.66) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL14982126 0.87 GSK3B (0.53) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL3828581 0.87 SLC2A1 (0.55) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL14982134 0.87 GSK3B (0.53) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL3829986 0.87 MAPT (0.59) GSK3BALDH1A1KDM4EMAPTNPC1
SCHEMBL60648 0.86 KMO (0.67) GSK3BALDH1A1HPGDKDM4EALOX15
SCHEMBL5634135 0.84 GSK3B (0.58) GSK3BALDH1A1HPGDKDM4EALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9535347-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-01-03 US disclosed
US-20140363759-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2014-12-11 US disclosed
US-20140363759-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2014-12-11 US disclosed
US-8841052-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2014-09-23 US disclosed
US-8841052-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2014-09-23 US disclosed
US-20140141362-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-05-22 US disclosed
US-20140141362-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-05-22 US disclosed
US-20130137023-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2013-05-30 US disclosed
US-20130137023-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2013-05-30 US disclosed
EP-0999835-B1 IMIDAZOLE DERIVATIVES AS MDR MODULATORS TAIJI BIOMEDICAL INC (US) 2009-09-09 EP disclosed
US-7279539-B2 Alkali-soluble polymer and polymerizable composition thereof FUJIFILM CORPORATION (JP) 2007-10-09 US disclosed
US-7279539-B2 Alkali-soluble polymer and polymerizable composition thereof FUJIFILM CORPORATION (JP) 2007-10-09 US disclosed
US-7232644-B2 Polymerizable composition and negative-working planographic printing plate precursor using the same FUJIFILM CORPORATION (JP) 2007-06-19 US disclosed
US-7232644-B2 Polymerizable composition and negative-working planographic printing plate precursor using the same FUJIFILM CORPORATION (JP) 2007-06-19 US disclosed
EP-0999835-A4 IMIDAZOLE DERIVATIVES AS MDR MODULATORS ONTOGEN CORP (US) 2004-08-25 EP disclosed
EP-0999835-A1 IMIDAZOLE DERIVATIVES AS MDR MODULATORS Ontogen Corporation (US) 2000-05-17 EP disclosed
WO-1999002155-A1 IMIDAZOLE DERIVATIVES AS MDR MODULATORS ONTOGEN CORPORATION (US) 1999-01-21 WO disclosed