Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | RHOC | P08134 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826994 | 0.83 | CFTR (0.46) | MAPK14MAPTGRM1KDM4ERAB9A | |
| SCHEMBL4735431 | 0.80 | MAPK14 (0.47) | MAPK14MAPTLMNAGRM1KDM4E | |
| SCHEMBL3061728 | 0.80 | LMNA (0.48) | MAPK14POLBMAPTLMNATP53 | |
| SCHEMBL3824769 | 0.79 | CFTR (0.55) | MAPTLMNAGRM1BCL2A1PDK1 | |
| SCHEMBL3824906 | 0.79 | DNM1L (0.45) | MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3829987 | 0.78 | DNM1L (0.44) | MAPT | |
| SCHEMBL3826390 | 0.77 | MAPT (0.50) | POLBMAPTLMNAKDM4ERAB9A | |
| SCHEMBL3071627 | 0.77 | LMNA (0.46) | MAPK14POLBMAPTLMNATP53 | |
| SCHEMBL4735436 | 0.76 | MAPK14 (0.41) | MAPK14POLBMAPTLMNATP53 | |
| SCHEMBL4738172 | 0.74 | AOC3 (0.42) | MAPK14LMNAGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |