Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2067964 | 0.79 | IDO1 (0.43) | CYP2C19HIF1APRSS1CTSGCTRB1 | |
| SCHEMBL30279715 | 0.79 | CYP2C19 (0.42) | GAAMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL2065630 | 0.78 | LMNA (0.52) | ALDH1A1LMNAPOLBRAB9AHTT | |
| SCHEMBL7075423 | 0.76 | KIF11 (0.44) | MEN1KMT2ATSHRCYP2C19CYP1A2 | |
| SCHEMBL27883761 | 0.76 | KCNN4 (0.44) | MEN1KMT2ATSHRCYP2C19ALDH1A1 | |
| SCHEMBL2065478 | 0.75 | MEN1 (0.50) | MEN1KMT2ATSHRCYP2C19CYP1A2 | |
| SCHEMBL342226 | 0.74 | ALDH1A1 (0.38) | KMT2ATSHRCYP2C19CYP1A2ALDH1A1 | |
| SCHEMBL3112777 | 0.73 | CYP2C19 (0.47) | KMT2ACYP2C19KCNN4HIF1AHDAC3 | |
| SCHEMBL9684810 | 0.72 | CYP2C19 (0.56) | MEN1KMT2ACYP2C19KCNN4HIF1A | |
| SCHEMBL9684808 | 0.72 | CYP2C19 (0.56) | MEN1KMT2ACYP2C19KCNN4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |