Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414089 | 0.81 | LMNA (0.41) | LMNACYP2C19 | |
| SCHEMBL10595209 | 0.77 | CYP2C19 (0.38) | LMNACYP2C19TDP1FDPSBLM | |
| SCHEMBL7762353 | 0.76 | TDP1 (0.33) | TDP1KDM4ETSHRFDPSBLM | |
| SCHEMBL5812370 | 0.75 | CYP2C19 (0.33) | LMNACYP2C19 | |
| SCHEMBL28529710 | 0.74 | CYP2C19 (0.34) | LMNACYP2C19TDP1KDM4EFDPS | |
| SCHEMBL5968456 | 0.73 | LMNA (0.50) | LMNACYP2C19TSHR | |
| SCHEMBL7537720 | 0.72 | LMNA (0.48) | LMNACYP2C19 | |
| SCHEMBL3244386 | 0.69 | LMNA (0.56) | LMNACYP2C19TDP1KDM4ETSHR | |
| SCHEMBL31567929 | 0.69 | — | — | |
| SCHEMBL28483902 | 0.67 | FDPS (0.41) | TDP1FDPSBLMSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394990-A1 | INDOLINE DERIVATIVES | Kyoto University (JP) | 2011-12-14 | — | — | EP | disclosed |
| US-20110294850-A1 | INDOLINE DERIVATIVES | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2011-12-01 | — | — | US | disclosed |
| EP-1300395-B1 | 4-SUBSTITUTED PIPERIDINE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2009-09-02 | — | — | EP | disclosed |
| EP-1209151-B1 | 4-SUBSTITUTED PIPERIDINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2007-04-25 | — | — | EP | disclosed |
| US-7091218-B1 | 4-substituted piperidine compound | EISAI CO., LTD. (JP) | 2006-08-15 | — | — | US | disclosed |
| US-6906083-B2 | 4-substituted piperidine compound | EISAI CO., LTD. (JP) | 2005-06-14 | — | — | US | disclosed |
| US-20050026895-A1 | 4-Substituted piperidine compound | EISAI CO., LTD. | 2005-02-03 | — | — | US | disclosed |
| US-20030166925-A1 | 4-Substituted piperidine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1300395-A1 | 4-SUBSTITUTED PIPERIDINE COMPOUND | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |
| EP-1209151-A1 | 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2002-05-29 | — | — | EP | disclosed |
| US-4950658-A | Method of medical treatment of Alzheimer's disease | BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIV. (US) | 1990-08-21 | — | — | US | disclosed |
| WO-1990006122-A1 | METHOD OF MEDICAL TREATMENT OF ALZHEIMER'S DISEASE | THE BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) | 1990-06-14 | — | — | WO | disclosed |
| EP-0100856-A1 | Formulations effective against ectoparasites | A. Nattermann & Cie. GmbH (DE) | 1984-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026895-A1 | 4-Substituted piperidine compound | ACHE, CHRM2, CHRM1 | LMNA 3157/4885CYP2C19 557/4885TDP1 2020/4885 |
| US-20110294850-A1 | INDOLINE DERIVATIVES | BCHE, ACHE, INMT | LMNA 3177/4885CYP2C19 182/4885TDP1 1157/4885 |
| US-20030166925-A1 | 4-Substituted piperidine compound | ACHE, CHRM4, CHRM1 | LMNA 3613/4885CYP2C19 851/4885TDP1 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.