Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | HPD | P32754 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097011 | 0.85 | SLC16A1 (0.47) | SLC16A1 | |
| SCHEMBL3832025 | 0.84 | ADORA2B (0.40) | SLC16A1HPDALDH1A1ADORA2BGSK3A | |
| SCHEMBL3831679 | 0.72 | SLC16A1 (0.45) | SLC16A1ALDH1A1ADORA2BADORA2AADORA1 | |
| SCHEMBL18096860 | 0.67 | ADORA2B (0.44) | ADORA2BADORA2AADORA1 | |
| SCHEMBL4841558 | 0.66 | SLC16A1 (0.43) | SLC16A1HPDADORA2B | |
| SCHEMBL3829617 | 0.66 | ALDH1A1 (0.38) | SLC16A1ALDH1A1ADORA2BADORA2AADORA1 | |
| SCHEMBL5096911 | 0.65 | SLC16A1 (0.44) | SLC16A1 | |
| SCHEMBL3833867 | 0.60 | ALDH1A1 (0.39) | SLC16A1ALDH1A1ADORA2BADORA2AADORA1 | |
| SCHEMBL18097326 | 0.60 | ADORA2B (0.53) | ADORA2BADORA2AADORA1 | |
| SCHEMBL19993561 | 0.59 | GSK3B (0.47) | HPDALDH1A1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414825-B9 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2009-09-16 | — | — | EP | disclosed |
| EP-1414825-B1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2007-09-26 | — | — | EP | disclosed |