Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 14/20 | 0.67 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164711 | 1.00 | GRIA4 (0.67) | GRIA4GRIA2GRIA1GRIA3SCN5A | |
| SCHEMBL338352 | 0.88 | GRIA4 (0.54) | GRIA4GRIA2GRIA1GRIA3SCN5A | |
| SCHEMBL338482 | 0.88 | GRIA4 (0.54) | GRIA4GRIA2GRIA1GRIA3SCN5A | |
| SCHEMBL5794639 | 0.81 | GRIA4 (0.67) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5878067 | 0.80 | GRIA4 (0.91) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL4950547 | 0.77 | TDP1 (0.47) | GRIA4ROCK2ROCK1GRM5 | |
| SCHEMBL28571512 | 0.74 | XDH (0.48) | GRM5 | |
| SCHEMBL4947733 | 0.74 | XDH (0.40) | SCN5ASCN9AROCK2ROCK1GRM5 | |
| SCHEMBL4949007 | 0.74 | GRM5 (0.36) | GRIA4SCN5ASCN9AROCK2ROCK1 | |
| SCHEMBL5878509 | 0.74 | GRIA4 (0.80) | GRIA4GRIA2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102153-A1 | AMPA RECEPTOR POTENTIATORS | Eli Lilly & Company (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008073789-A1 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY (US) | 2008-06-19 | — | — | WO | disclosed |