Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.52 |
| ▸ | ITGAV | P06756 | 12/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656305 | 0.80 | ITGB3 (0.51) | ITGB3ITGAVITGA2BMAPTLMNA | |
| SCHEMBL7659630 | 0.80 | ITGB3 (0.48) | ITGB3ITGAVITGA2BMAPTKMT2A | |
| SCHEMBL382789 | 0.78 | ITGB3 (0.45) | ITGB3ITGAVITGA2BMAPTKMT2A | |
| SCHEMBL7660996 | 0.78 | ITGB3 (0.51) | ITGB3ITGAVITGA2B | |
| SCHEMBL382345 | 0.77 | ITGB3 (0.55) | ITGB3ITGAVITGA2BKMT2AALDH1A1 | |
| SCHEMBL383255 | 0.77 | MAPT (0.40) | ITGB3ITGAVITGA2BMAPTGAA | |
| SCHEMBL382270 | 0.76 | ITGB3 (0.86) | ITGB3ITGAVITGA2B | |
| SCHEMBL381992 | 0.76 | ITGB3 (0.86) | ITGB3ITGAVITGA2B | |
| SCHEMBL382971 | 0.76 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPTTP53 | |
| SCHEMBL7659624 | 0.76 | ITGB3 (0.41) | ITGB3ITGAVITGA2BMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |