Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473336 | 0.77 | HDAC8 (0.57) | POLBHTTHDAC8HDAC1HDAC2 | |
| SCHEMBL8899318 | 0.76 | NOTUM (0.68) | POLBHTTKMT2AALOX12MAPT | |
| SCHEMBL19836145 | 0.75 | MAPK14 (0.55) | POLBHDAC8KMT2AMAPTMEN1 | |
| SCHEMBL17383550 | 0.74 | MAPT (0.56) | POLBHTTKMT2AALOX12MAPT | |
| SCHEMBL2640766 | 0.74 | ALDH1A1 (0.70) | POLBHTTKMT2AALOX12MAPT | |
| Trifluoroacetic Acid SCHEMBL3823846 | 0.73 | NOTUM (0.55) | POLBHTTHDAC8KMT2AALOX12 | |
| SCHEMBL24987981 | 0.73 | SMN1; SMN2 (0.76) | POLBKMT2AALOX12MAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL17377397 | 0.73 | MAPT (0.55) | POLBHTTKMT2AALOX12MAPT | |
| SCHEMBL25914400 | 0.73 | MAOB (0.53) | POLBHTTKMT2AALOX12MAPT | |
| SCHEMBL14438048 | 0.73 | KMT2A (0.62) | POLBHTTKMT2AALOX12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096111-A1 | PYRAZOLES AND USE THEREOF AS DRUGS | Japan Tobacco Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO, INC. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | PYGL, GYS2, G6PC1 | POLB 2667/4885HTT 4408/4885HDAC8 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.