Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGAV | P06756 | 4/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382402 | 0.88 | ITGB3 (0.40) | ITGB3ITGAVGRIN2BALDH1A1LMNA | |
| SCHEMBL382988 | 0.85 | PRMT5 (0.38) | ITGB3ITGAVPRMT5GRIN2BSYK | |
| SCHEMBL383138 | 0.84 | ITGB3 (0.43) | ITGB3ITGAVDRD2DRD3 | |
| SCHEMBL381721 | 0.84 | ITGB3 (0.40) | ITGB3ITGAVPRMT5GRIN2BSYK | |
| SCHEMBL382802 | 0.83 | ITGB3 (0.37) | ITGB3ITGAVALDH1A1DRD2DRD3 | |
| SCHEMBL6499269 | 0.82 | VCP (0.40) | ITGB3ITGAVGRIN2BSYKALDH1A1 | |
| SCHEMBL382611 | 0.82 | ITGB3 (0.47) | ITGB3ITGAV | |
| SCHEMBL382612 | 0.80 | GAA (0.37) | ITGB3ITGAVPRMT5GRIN2BSYK | |
| SCHEMBL382613 | 0.79 | ITGB3 (0.42) | ITGB3ITGAVPRMT5GRIN2B | |
| SCHEMBL382989 | 0.79 | ITGB3 (0.36) | ITGB3ITGAVPRMT5GRIN2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |