SCHEMBL3830829

SCHEMBL3830829

COc1cc(F)c2nccc(O)c2c1.COc1ccc(N)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.42
NOS1 P29475 1/20 0.42
NOS2 P35228 1/20 0.42
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MEN1 O00255 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
THRB P10828 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41
KMT2A Q03164 1/20 0.41
MCL1 Q07820 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
DYRK1A Q13627 2/20 0.38
PLAU P00749 1/20 0.38
MAP3K14 Q99558 1/20 0.37
LMNA P02545 1/20 0.36
NPC1 O15118 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2923376 0.89 NOS3 (0.40) NOS3NOS1NOS2KDM4EMEN1
SCHEMBL4279169 0.81 NOS3 (0.43) NOS3NOS1NOS2KDM4EDYRK1A
Hydrochloric Acid SCHEMBL6640376 0.79 NOS3 (0.42) NOS3NOS1NOS2KDM4EALDH1A1
Hydrochloric Acid SCHEMBL5748572 0.79 NOS3 (0.42) NOS3NOS1NOS2KDM4EALDH1A1
Oxalic Acid SCHEMBL5264185 0.76 LMNA (0.41) NOS3NOS1NOS2KDM4EALDH1A1
SCHEMBL112473 0.75 ALDH1A1 (0.57) NOS3NOS1NOS2KDM4EALDH1A1
Hydrochloric Acid SCHEMBL1682378 0.73 ALDH1A1 (0.61) NOS3NOS1NOS2KDM4EALDH1A1
Fumaric Acid SCHEMBL5316999 0.73 KDM4E (0.40) NOS3NOS1NOS2KDM4EGAA
SCHEMBL24916103 0.73 NOS3 (0.41) NOS3NOS1NOS2KDM4EALDH1A1
SCHEMBL29924149 0.73 NOS3 (0.41) NOS3NOS1NOS2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1796466-A4 ANTIBACTERIAL AGENTS GLAXO GROUP LTD (GB) 2009-09-02 EP disclosed
EP-1796466-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2007-06-20 EP disclosed
EP-1560488-A4 ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM CORP (US) 2006-08-02 EP disclosed
WO-2006002047-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2006-01-05 WO disclosed
EP-1560488-A2 ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM CORPORATION (US) 2005-08-10 EP disclosed
EP-1470125-A1 AMINOPIPERIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2004-10-27 EP disclosed
WO-2004041210-A2 ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM CORPORATION (US) 2004-05-21 WO disclosed
EP-1399443-A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2004-03-24 EP disclosed
WO-2003087098-A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2003-10-23 WO disclosed
WO-2003064421-A1 AMINOPIPERIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-08-07 WO disclosed