Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830838 | 0.88 | GLA (0.49) | ATMCHRM2CHRM1GLAALDH1A1 | |
| SCHEMBL166860 | 0.85 | ATM (0.57) | ATMGLAALDH1A1LMNAKMT2A | |
| SCHEMBL13086293 | 0.79 | CHRM2 (0.40) | ATMCHRM2CHRM1ALDH1A1KDM4E | |
| SCHEMBL111438 | 0.78 | TSHR (0.58) | CHRM2CHRM1GLAALDH1A1KDM4E | |
| SCHEMBL20123359 | 0.77 | ATM (0.50) | ATMGLAALDH1A1KDM4ELMNA | |
| SCHEMBL15142912 | 0.77 | TSHR (0.51) | ATMALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL8267288 | 0.76 | GLA (0.56) | ATMGLAALDH1A1KDM4EKMT2A | |
| SCHEMBL7106263 | 0.76 | TSHR (0.61) | CHRM2CHRM1ALDH1A1KDM4ELMNA | |
| SCHEMBL65273 | 0.76 | TDP1 (0.55) | ATMGLAALDH1A1KDM4ELMNA | |
| SCHEMBL166861 | 0.76 | ALDH1A1 (0.56) | ATMGLAALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102158-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | Topo Target A/S (DK) | 2009-09-23 | — | — | EP | claimed |
| WO-2008071387-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | TOPOTARGET A/S (DK) | 2008-06-19 | — | — | WO | claimed |
| EP-2102158-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | Topo Target A/S (DK) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071387-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | TOPOTARGET A/S (DK) | 2008-06-19 | — | — | WO | disclosed |