Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norgestimate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 7/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 4/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | AR | P10275 | 6/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norgestimate SCHEMBL633395 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL5523236 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL5173707 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL1411821 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL15233395 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL38318 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL28685734 | 0.99 | PGR (0.98) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL7532415 | 0.91 | PGR (0.84) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| SCHEMBL24574056 | 0.91 | PGR (0.84) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| SCHEMBL11699972 | 0.89 | PGR (0.80) | PGRSLC6A4NR3C1ADORA3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8878 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12616703-B2 | Methods of contraception using nomegestrol acetate and estradiol | Theramex HQ UK Limited (GB) | 2026-05-05 | — | — | US | claimed |
| EP-4440706-B1 | COMPOSITIONS FOR PROMOTING HAIR GROWTH | ESTETRA SRL (BE) | 2026-04-29 | — | — | EP | claimed |
| US-20260091041-A1 | Methods of Treating Heavy Menstrual Bleeding | ABBVIE INC (US) | 2026-04-02 | — | — | US | claimed |
| US-20260090995-A1 | ORODISPERSIBLE DOSAGE UNIT CONTAINING AN ESTETROL COMPONENT | ESTETRA SRL (BE) | 2026-04-02 | — | — | US | claimed |
| US-20260053736-A1 | LONG ACTING DRUG DELIVERY DEVICE AND ITS USE IN CONTRACEPTION | BAYER OY (FI) | 2026-02-26 | — | — | US | claimed |
| EP-4680240-A1 | METHOD OF TREATING DISORDERS WITH SURF1 MALFUNCTION | Cure Mito Foundation (US) | 2026-01-21 | — | — | EP | claimed |
| US-20260000613-A1 | INJECTABLE CONTROLLED-RELEASE FORMULATIONS OF PROGESTOGEN DRUGS | FORDOZ PHARMA CORP. (US) | 2026-01-01 | — | — | US | claimed |
| EP-4643858-A1 | METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF UTERINE DISEASE | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-11-05 | — | — | EP | claimed |
| EP-4239331-B1 | A METHOD OF PROCESSING A BIOLOGICAL SAMPLE | METABOLOMIC DIAGNOSTICS LTD (IE) | 2025-11-05 | — | — | EP | claimed |
| EP-4637777-A1 | USE OF ESTETROL IN HEPATICALLY IMPAIRED PATIENTS | Estetra SRL (BE) | 2025-10-29 | — | — | EP | claimed |
| WO-1990014075-A1 | OSMOTIC DOSAGE FORM | ALZA CORPORATION (US) | 1990-11-29 | — | — | WO | claimed |
| US-4948593-A | SUSTAINED AND CONTROLLED CONTRACEPTION | ALZA CORPORATION (US) | 1990-08-14 | — | — | US | claimed |
| CN-1041528-A | HORMONE PREPARATION AND METHOD | JENCAP RESEARCH LTD (CA) | 1990-04-25 | — | — | CN | claimed |
| US-4906169-A | Transdermal estrogen/progestin dosage unit, system and process | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1990-03-06 | — | — | US | claimed |
| WO-1989005663-A1 | TRANSDERMAL ESTROGEN/PROGESTIN DOSAGE UNIT, SYSTEM AND PROCESS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1989-06-29 | — | — | WO | claimed |
| EP-0309263-A2 | Hormone composition and use | JENCAP RESEARCH LIMITED (CA) | 1989-03-29 | — | — | EP | claimed |
| CN-87108380-A | Transdermal estrogen/progestin dosage units, systems, and methods | — | 1988-08-24 | — | — | CN | claimed |
| EP-0275716-A1 | Transdermal estrogen/progestin dosage unit, and fertility control kit comprising said dosage unit. | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1988-07-27 | — | — | EP | claimed |
| US-4616006-A | ADMINISTERING COMBINATIONS OF ESTROGEN AND PROGESTOGEN | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-10-07 | — | — | US | claimed |
| US-4544554-A | STEROID COMBINATION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1985-10-01 | — | — | US | claimed |