Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norgestimate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 7/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 4/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | AR | P10275 | 6/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norgestimate SCHEMBL15233395 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL38317 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL5173707 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL1411821 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL633395 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL38318 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL28685734 | 0.99 | PGR (0.98) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL7532415 | 0.91 | PGR (0.84) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| SCHEMBL24574056 | 0.91 | PGR (0.84) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| SCHEMBL11699972 | 0.89 | PGR (0.80) | PGRSLC6A4NR3C1ADORA3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500793-A1 | OSMOTIC, ORAL DOSAGE FORM FOR FERTILITY CONTROL. | ALZA CORP (US) | 1992-09-02 | — | — | EP | claimed |
| WO-1991007173-A1 | OSMOTIC, ORAL DOSAGE FORM FOR FERTILITY CONTROL | ALZA CORPORATION (US) | 1991-05-30 | — | — | WO | claimed |
| US-20070213543-A1 | PREVENTION OF OVARIAN CANCER BY ADMINISTRATION OF AGENTS THAT INDUCE BIOLOGIC RESPONSES | RODRIGUEZ GUSTAVO C | 2007-09-13 | — | — | US | disclosed |