Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Norgestimate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 7/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 4/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | AR | P10275 | 6/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norgestimate SCHEMBL5523236 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL5173707 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL38317 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL1411821 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL15233395 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL38318 | 1.00 | PGR (1.00) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL28685734 | 0.99 | PGR (0.98) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| Norgestimate SCHEMBL7532415 | 0.91 | PGR (0.84) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| SCHEMBL24574056 | 0.91 | PGR (0.84) | PGRSLC6A4NR3C1ADORA3SLC6A2 | |
| SCHEMBL11699972 | 0.89 | PGR (0.80) | PGRSLC6A4NR3C1ADORA3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585024-B1 | ONCE-A-MONTH METHOD OF CONTRACEPTION | HRA PHARMA LAB (FR) | 2015-11-25 | — | — | EP | claimed |
| US-20130090318-A1 | ONCE-A-MONTH METHOD OF CONTRACEPTION | LABORATOIRE HRA-PHARMA (FR) | 2013-04-11 | — | — | US | claimed |
| EP-2399566-A1 | Once-a-month method of contraception | Laboratoire HRA Pharma (FR) | 2011-12-28 | — | — | EP | claimed |
| EP-0309263-B1 | Hormone composition and use | JENCAP RESEARCH LTD (CA) | 1994-03-09 | — | — | EP | claimed |
| EP-2779996-B1 | DRUG DELIVERY SYSTEM FOR SUSTAINED DELIVERY OF BIOACTIVE AGENTS | UPM KYMMENE CORP (FI) | 2024-04-10 | — | — | EP | disclosed |
| US-11389537-B2 | Drug delivery system for sustained delivery of bioactive agents | UPM-KYMMENE CORPORATION (FI) | 2022-07-19 | — | — | US | disclosed |
| US-10772897-B2 | Method for on-demand contraception | LABORATOIRE HRA-PHARMA (FR) | 2020-09-15 | — | — | US | disclosed |
| US-20190209583-A1 | METHOD FOR ON-DEMAND CONTRACEPTION | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2019-07-11 | — | — | US | disclosed |
| US-10159681-B2 | Method for on-demand contraception | LABORATOIRE HRA-PHARMA (FR) | 2018-12-25 | — | — | US | disclosed |
| US-9616073-B2 | Method for on-demand contraception | LABORATOIRE HRA-PHARMA (FR) | 2017-04-11 | — | — | US | disclosed |
| EP-3106167-A1 | METHOD FOR ON-DEMAND CONTRACEPTION | Laboratoire HRA Pharma (FR) | 2016-12-21 | — | — | EP | disclosed |
| US-20160317555-A1 | METHOD FOR ON-DEMAND CONTRACEPTION | LABORATOIRE HRA-PHARMA (FR) | 2016-11-03 | — | — | US | disclosed |
| US-5585370-A | Hormone preparation and method | JENCAP RESEARCH LTD. (CA) | 1996-12-17 | — | — | US | disclosed |
| US-5382573-A | Hormone preparation and method | JENCAP RESEARCH LTD. (CA) | 1995-01-17 | — | — | US | disclosed |
| EP-0309263-B1 | Hormone composition and use | JENCAP RESEARCH LTD (CA) | 1994-03-09 | — | — | EP | disclosed |
| US-5276022-A | Hormone preparation and method | JENCAP RESEARCH LTD. (CA) | 1994-01-04 | — | — | US | disclosed |
| US-5256421-A | Hormone preparation and method | JENCAP RESEARCH LTD. (CA) | 1993-10-26 | — | — | US | disclosed |
| EP-0559240-A2 | Hormone composition containing estrogen and mogestin | JENCAP RESEARCH LIMITED (CA) | 1993-09-08 | — | — | EP | disclosed |
| US-5108995-A | HORMONE PREPARATION AND METHOD | JENCAP RESEARCH LTD. (CA) | 1992-04-28 | — | — | US | disclosed |
| EP-0309263-A2 | Hormone composition and use | JENCAP RESEARCH LIMITED (CA) | 1989-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10159681-B2 | Method for on-demand contraception | GNRHR, CYP17A1, CYP19A1 | PGR 7/4885SLC6A4 1916/4885NR3C1 72/4885 |
| US-20190209583-A1 | METHOD FOR ON-DEMAND CONTRACEPTION | GNRHR, CYP17A1, CYP19A1 | PGR 7/4885SLC6A4 1916/4885NR3C1 72/4885 |
| US-20160317555-A1 | METHOD FOR ON-DEMAND CONTRACEPTION | GNRHR, CYP17A1, CYP19A1 | PGR 7/4885SLC6A4 1916/4885NR3C1 72/4885 |
| US-10772897-B2 | Method for on-demand contraception | GNRHR, CYP17A1, CYP19A1 | PGR 7/4885SLC6A4 1916/4885NR3C1 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.