Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
| ▸ | USP4 | Q13107 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28195451 | 0.84 | CYP19A1 (0.48) | CYP19A1L3MBTL1SMN1; SMN2LMNAGAA | |
| SCHEMBL27550728 | 0.78 | CYP19A1 (0.44) | CYP19A1L3MBTL1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL28006254 | 0.75 | KDM4E (0.55) | SMN1; SMN2LMNAGAAKMT2ATSHR | |
| SCHEMBL10753183 | 0.74 | LMNA (0.78) | L3MBTL1SMN1; SMN2LMNAGAAKMT2A | |
| SCHEMBL3290432 | 0.74 | HSD17B10 (0.56) | L3MBTL1SMN1; SMN2LMNAGAAKMT2A | |
| SCHEMBL11007879 | 0.74 | KMT2A (0.36) | L3MBTL1SMN1; SMN2KMT2ARAB9AALDH1A1 | |
| SCHEMBL10573912 | 0.74 | MAPK1 (0.61) | CYP19A1L3MBTL1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL3832728 | 0.72 | L3MBTL1 (0.54) | L3MBTL1SMN1; SMN2LMNAKMT2AMAPK1 | |
| SCHEMBL1177985 | 0.72 | CYP19A1 (0.54) | CYP19A1L3MBTL1SMN1; SMN2LMNAGAA | |
| SCHEMBL2411339 | 0.71 | FEN1 (0.45) | L3MBTL1SMN1; SMN2LMNAGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | claimed |