Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29068282 | 0.83 | KIF11 (0.59) | CA1CA2CA9KMT2AALDH1A1 | |
| SCHEMBL2790323 | 0.80 | KMT2A (0.51) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL43401 | 0.79 | CYP19A1 (0.52) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL28307655 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1LMNAMAPTHTT | |
| Hydrochloric Acid SCHEMBL28780307 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL28122215 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL4587308 | 0.78 | HSD17B10 (0.52) | CA1CA2KMT2AHTTHSD17B10 | |
| SCHEMBL28847222 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1LMNAMAPTHTT | |
| Bromide SCHEMBL10492602 | 0.78 | CYP19A1 (0.50) | KMT2AALDH1A1LMNAMAPTHTT | |
| SCHEMBL11151702 | 0.78 | KMT2A (0.45) | KMT2AALDH1A1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102158-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | Topo Target A/S (DK) | 2009-09-23 | — | — | EP | claimed |
| WO-2008071387-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | TOPOTARGET A/S (DK) | 2008-06-19 | — | — | WO | claimed |
| EP-2102158-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | Topo Target A/S (DK) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071387-A1 | PRODRUGS OF DIPHENYL OX- INDOL- 2 -ONE COMPOUNDS FOR THE TREATMENT OF CANCERS | TOPOTARGET A/S (DK) | 2008-06-19 | — | — | WO | disclosed |