⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175142 | 1.00 | — | — | |
| SCHEMBL599696 | 1.00 | — | — | |
| SCHEMBL27360126 | 0.97 | ALDH1A1 (0.52) | — | |
| Iodomethane SCHEMBL8981617 | 0.95 | ALDH1A1 (0.50) | — | |
| SCHEMBL30213431 | 0.88 | ALDH1A1 (0.44) | — | |
| Levulinic Acid SCHEMBL30924217 | 0.86 | LMNA (0.61) | — | |
| SCHEMBL2343475 | 0.79 | ALDH1A1 (0.46) | — | |
| SCHEMBL27571000 | 0.79 | KDM4E (0.44) | — | |
| SCHEMBL791253 | 0.79 | — | — | |
| SCHEMBL2599566 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133667-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20180134665-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
| US-20170348324-A1 | DERIVATIVES OF BETULIN | GLAXOSMITHKLINE LLC (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170252356-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING HIV WITH DERIVATIVES OF BETULIN | GLAXOSMITHKLINE LLC | 2017-09-07 | — | — | US | disclosed |
| US-20170022242-A1 | NOVEL ANTIVIRAL AND ANTITUMORAL COMPOUNDS | Katholieke Universiteit Leuven, KU LEUVEN R&D (BE) | 2017-01-26 | — | — | US | disclosed |
| US-9340513-B2 | Propenoate derivatives of betulin | GLAXOSMITHKLINE LLC (US) | 2016-05-17 | — | — | US | disclosed |
| US-20160120878-A1 | DERIVATIVES OF BETULIN | GLAXOSMITHKLINE LLC | 2016-05-05 | — | — | US | disclosed |
| US-9102685-B2 | Derivatives of betulin | GLAXOSMITHKLINE LLC (US) | 2015-08-11 | — | — | US | disclosed |
| US-20150218142-A1 | Derivatives of Betulin | GLAXOSMITHKLINE LLC (US) | 2015-08-06 | — | — | US | disclosed |
| US-20140357643-A1 | Derivatives of Betulin | GLAXOSMITHKLINE LLC | 2014-12-04 | — | — | US | disclosed |
| US-20060199822-A1 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-09-07 | — | — | US | disclosed |
| US-7091219-B2 | Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1586558-A2 | Bis-sulfonamide hydroxyethylamino retroviral protease inhinitors | G.D. Searle LLC. (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040063771-A1 | Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2004-04-01 | — | — | US | disclosed |
| US-6569882-B2 | Viricides; enzyme inhibitors | G. D. SEARLE & CO. | 2003-05-27 | — | — | US | disclosed |
| US-20030013751-A1 | Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2003-01-16 | — | — | US | disclosed |
| US-6384036-B1 | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors | G.D. SEARLE & CO. | 2002-05-07 | — | — | US | disclosed |
| US-6143747-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0804428-A1 | BIS-SULFONAMIDE HYDROXYETHYLAMINO RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996022287-A1 | BIS-SULFONAMIDE HYDROXYETHYLAMINO RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-07-25 | — | — | WO | disclosed |