Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837345 | 0.89 | MYC (0.47) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL21590178 | 0.87 | MYC (0.57) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL27925971 | 0.86 | KEAP1 (0.59) | KEAP1NFE2L2PARP1KDM4EHSD17B10 | |
| SCHEMBL28471957 | 0.82 | MYC (0.59) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL3834194 | 0.81 | KDM4E (0.54) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL28031422 | 0.81 | KDM4E (0.54) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL6389889 | 0.81 | ALDH1A1 (0.55) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL4138458 | 0.80 | MYC (0.72) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL15562846 | 0.80 | MYC (0.57) | MYCKEAP1NFE2L2PARP1KDM4E | |
| SCHEMBL28110786 | 0.80 | PLA2G7 (0.52) | MYCKDM4EALDH1A1LMNADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | claimed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | claimed |