Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 2/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850548 | 0.85 | HCRTR1 (0.54) | ALDH1A1KDM4EHCRTR1TSHRF2 | |
| SCHEMBL11851628 | 0.82 | GAA (0.49) | ALDH1A1TSHRLMNACYP1A2CYP2D6 | |
| SCHEMBL10420166 | 0.81 | ALDH1A1 (0.57) | ALDH1A1HPGDCNR2KDM4EHCRTR1 | |
| SCHEMBL27797840 | 0.81 | CDC25B (0.44) | ALDH1A1HPGDKDM4ECDC25BGLA | |
| SCHEMBL9124654 | 0.80 | GAA (0.44) | ALDH1A1HPGDKDM4ETSHRLMNA | |
| SCHEMBL9180166 | 0.80 | TSHR (0.59) | ALDH1A1KDM4EHCRTR1TSHRF2 | |
| SCHEMBL9074960 | 0.79 | TSHR (0.47) | ALDH1A1KDM4ETSHRLMNACYP2D6 | |
| SCHEMBL9789350 | 0.79 | HTT (0.53) | ALDH1A1KDM4EHIF1APOLBHTR6 | |
| SCHEMBL7318545 | 0.79 | POLB (0.55) | ALDH1A1HPGDKDM4ETSHRPOLB | |
| SCHEMBL28748514 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDCNR2KDM4EHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |
| US-7091209-B2 | Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors | MERCK & CO., INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20040106627-A1 | Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECULARE P ANGELETTI SPA (IT) | 2004-06-03 | — | — | US | disclosed |
| EP-1309566-A1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002006246-A1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106627-A1 | Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors | DPYD, DUT, UMPS | ALDH1A1 23/4885HPGD 809/4885CNR2 4479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.